In-situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers under static and dynamic conditions
Name
Hammond_In-situ monitoring.pdf
Size
10.1 MB
Format
Adobe PDF
Checksum (MD5)
ccc14f35011440719a5cadfad018fef1
Author(s)
Tian, Fei
Min, Jouha
Kanka, Jiri
Du, Henry
Hammond, Paula T
Date Issued
June 2015
Journal
Proceedings of SPIE--the International Society for Optical Engineering
Publisher
SPIE
Citation
Tian, Fei, Jouha Min, Jiri Kanka, Paula T. Hammond, and Henry Du. “In-Situ Monitoring of Drug Release from Therapeutic Eluting Polyelectrolyte Multilayers Under Static and Dynamic Conditions.” Edited by Gary Pickrell, Eric Udd, and Henry H. Du. Fiber Optic Sensors and Applications XII (June 3, 2015). © 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Version
Final published version
Abstract
The release profiles of gentamicin sulfate (GS) from [chitosan (CHI)/poly(acrylic acid) (PAA)/GS/PAA]n polyelectrolyte multilayers were investigated in situ using an innovative lab-on-fiber (LOF) optofluidic platform that mimics physiologically relevant fluid flow in a microenvironment. The LOF was constructed by enclosing in a flow-enabled and optically coupled glass capillary a long-period fiber grating both as a substrate for LbL growth of [CHI/PAA/GS/PAA]n and a measurement probe for GS release. We show that the LOF is very robust in monitoring the construction of the [CHI/PAA/GS/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release with high sensitivity. The release processes in the LOF under static and a range of dynamic conditions are evaluated, showing a faster release under dynamic condition than that under static condition due to the varying circumstance of GS concentration gradient and the effect of flow-induced shear at the medium-multilayer interface. The LOF platform has the potential to be a powerful test bed to facilitate the design and evaluation of drug-eluting polyelectrolyte thin films for their clinical insertion as part of patient care strategy.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1117/12.2191683
