Photothermal Genetic Engineering
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ACS_kd_pa_final.pdf
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Author(s)
Deisseroth, Karl
Anikeeva, Polina Olegovna
Date Issued
September 2012
Journal
ACS Nano
Publisher
American Chemical Society (ACS)
Citation
Anikeeva, Polina, and Karl Deisseroth. “Photothermal Genetic Engineering.” ACS Nano 6, no. 9 (September 25, 2012): 7548-7552.
Version
Author's final manuscript
Abstract
Optical methods for manipulation of cellular function have enabled deconstruction of genetic and neural circuits in vitro and in vivo. Plasmonic gold nanomaterials provide an alternative platform for external optical manipulation of genetic circuits. The tunable absorption of gold nanoparticles in the infrared spectral region and straightforward surface functionalization has led to applications in intracellular delivery and photorelease of short RNAs, recently enabling bidirectional photothermal modulation of specific genes via RNA interference (RNAi). We discuss recent advances in optical gene circuit engineering and plasmonic nanomaterials, as well as future research opportunities and challenges in photothermal gene manipulation.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Research Laboratory of Electronics
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1021/nn3039287
