Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells
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Author(s)
Xu, Ying-Qi
Chen, Wen-Rong
Tsosie, Jonathan
Xie, Xi
Li, Peng
Wan, Jian-Bo
He, Cheng-Wei
Chen, Mei-He
Date Issued
July 2016
Journal
Journal of Nanomaterials
Publisher
Hindawi Publishing Corporation
Citation
Xu, Ying-Qi, Wen-Rong Chen, Jonathan K. Tsosie, Xi Xie, Peng Li, Jian-Bo Wan, Cheng-Wei He, and Mei-Wan Chen. “Niosome Encapsulation of Curcumin: Characterization and Cytotoxic Effect on Ovarian Cancer Cells.” Journal of Nanomaterials 2016 (2016): 1-9.
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Final published version
Abstract
Curcumin, a natural chemical compound found in Curcuma longa, has been applied in multiple medicinal areas from antibiotic to antitumor treatment. However, the chemical structure of curcumin results in poor stability, low solubility, and rapid degradation in vivo, hindering its clinical utilization. To address these issues, we have developed a novel niosome system composed of nonionic surfactants: Span 80, Tween 80, and Poloxamer 188. Curcumin was encapsulated in the niosomes with a high entrapment efficiency of 92.3 [plus or minus] 0.4%. This system provided controlled release of curcumin, thereby improving its therapeutic capability. Dynamic dialysis was conducted to evaluate the in vitro drug release of curcumin-niosomes. Curcumin-niosomes exhibited enhanced cytotoxic activity and apoptotic rate against ovarian cancer A2780 cells compared with freely dispersed curcumin. These results demonstrate that the curcumin-niosome system is a promising strategy for the delivery of curcumin and ovarian cancer therapy.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1155/2016/6365295
