A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion
Name
nihms-987466.pdf
Description
Accepted version
Size
97.63 KB
Format
Adobe PDF
Checksum (MD5)
a39c899756efbf8331ad5cea4c23cea0
Author(s)
Horton, Brendan
Spranger, Stefani
Date Issued
July 2018
Journal
Immunity
Publisher
Elsevier BV
Citation
Horton, Brendan and Stefani Spranger. "A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion." Immunity 49 (2018): 11-13 © 2018 The Author(s)
Version
Final published version
Abstract
Pancreatic adenocarcinoma (PDAC) is mostly refractory to immunotherapies. In this issue of Immunity, Li et al. (2018) generate a library of clonal PDAC tumors to examine the tumor-intrinsic features shaping the anti-tumor immune response and find that tumor cell-derived CXCL1 directly blunts T cell infiltration and reduces responsiveness to immunotherapy.
Subjects
Immunology
Immunology and Allergy
Infectious Diseases
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.immuni.2018.07.001
