Interstitial Flow and Effects on Tumor Cell Migration
Author(s)
Polacheck III, William Joseph
Kamm, Roger Dale
Date Issued
June 2010
Journal
ASME 2010 Summer Bioengineering Conference, Parts A and B
Publisher
ASME International
Citation
Polacheck, William, and Roger Kamm. “Interstitial Flow and Effects on Tumor Cell Migration.” Proceedings of the ASME 2010 Summer Bioengineering Conference, 16-19 June, 2010, Naples, Florida, ASME. © 2010 by ASME
Version
Final published version
Abstract
Interstitial flow is the convective transport of fluid through tissue extracellular matrix. This creeping fluid flow has been shown to be important in regulating the development, function, and pathology of tissues. Furthermore, interstitial flow has been shown to affect the morphology and migration of cells such as fibroblasts, cancer cells, endothelial cells, and mesenchymal stem cells (1). Chary and Jain used fluorescence recovery after photobleaching to directly observe fluid flow in the tissue interstitium and determined typical flow velocities are on the order of 0.1–2.0μm/s (2). Interstitial flow is particularly important in driving transport in tumor tissues, as neoplastic tissue is often characterized by increased interstitial pressure (3).
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1115/SBC2010-19446
