Association of hypermagnesemia and blood pressure in the critically ill
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Author(s)
Nelson, Rachel
Alper, Seth L.
Mukamal, Kenneth J.
Danziger, John
Scott, Daniel
Celi, Leo Anthony G.
Lee, Joonwu
Mark, Roger G
Date Issued
November 2013
Journal
Journal of Hypertension
Publisher
Wolters Kluwer - Lippincott Williams & Wilkins
Citation
Celi, Leo A. et al. “Association of Hypermagnesemia and Blood Pressure in the Critically Ill.” Journal of Hypertension 31, 11 (November 2013): 2136–2141. © 2013 Wolters Kluwer Health Lippincott Williams & Wilkins
Version
Author's final manuscript
Abstract
BACKGROUND: Although magnesium is important in the biology of blood pressure regulation, little clinical data exist on the association of hypermagnesemia and blood pressure. METHOD:: We examined the association of hypermagnesemia and SBP in a cross-sectional study of 10 521 ICU patients from a single tertiary care medical center, 6% of whom had a serum magnesium above 2.6 mg/dl at time of admission. RESULTS:: In a multivariable analysis, hypermagnesemia was associated with SBP 6.2 mmHg lower [95% confidence interval (CI) -8.2, -4.2, P < 0.001] than in patients with admission values of serum magnesium 2.6 mg/dl or less. Each mg/dl increase in serum magnesium was associated with a decrease in SBP of 4.3 mmHg (95% CI -5.5, -3.1, P < 0.001). In addition, hypermagnesemic patients had a 2.48-fold greater likelihood (95% CI 2.06, 3.00, P < 0.001) of receiving intravenous vasopressors during the first 24h of ICU care, independent of admission SBP. CONCLUSION:: Our findings add support to the biologic importance of magnesium regulation in blood pressure control.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
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DOI of Published Version
https://doi.org/10.1097/HJH.0B013E3283642F18
