Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer’s Disease
Author(s) • •
Blanchard, Joel W.
Tsai, Li-Huei
Blanchard, Joel W.
Date Issued
March 2019
Journal
Cell Stem Cell
Publisher
Elsevier BV
Citation
Blanchard, Joel W. and Tsai, Li-Huei. "Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer’s Disease." Cell Stem Cell 24, 3 (March 2019): 347-349 © 2019 Elsevier
Version
Author's final manuscript
Abstract
Conflicting clinical studies have reported that statins both reduce and accelerate cognitive impairments in Alzheimer’s disease. In this issue, Van der Kant et al. (2019) use iPSC-derived neurons to thoroughly dissect the link between cholesterol synthesis, phospho-Tau, and amyloid-β, revealing new therapeutic opportunities in Alzheimer’s disease and related dementias.
MIT Department
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.stem.2019.02.003