CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes
Name
nihms959317.pdf
Description
Accepted version
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1.08 MB
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Checksum (MD5)
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Author(s)
Zhou, Yujing
Engl, Oliver D.
Bandar, Jeffrey
Chant, Emma D.
Buchwald, Stephen Leffler
Date Issued
May 2018
Journal
Angewandte Chemie International Edition
Publisher
Wiley
Citation
Zhou, Yujing, et al. "CuH-Catalyzed Asymmetric Hydroamidation of Vinylarenes." Angewandte Chemie International Edition 57, 22 (May 2018): p. 6672-75 doi 10.1002/ANIE.201802797 ©2018 Author(s)
Version
Author's final manuscript
Abstract
A CuH-catalyzed enantioselective hydroamidation reaction of vinylarenes has been developed using readily accessible 1,4,2-dioxazol-5-ones as electrophilic amidating reagents. This method provides a straightforward and efficient approach to synthesize chiral amides in good yields with high levels of enantiopurity under mild conditions. Moreover, this transformation tolerates substrates bearing a broad range of functional groups.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/ANIE.201802797
