Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections
Name
PhysRevLett.122.028101.pdf
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492.79 KB
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Author(s)
Nia, Hadi Tavakoli
Sellon, Jonathan Blake
Azadi Sohi, Mojtaba
Oftadeh, Ramin
Ghaffari, Roozbeh
Grodzinsky, Alan J
Freeman, Dennis M
Date Issued
January 2019
Journal
Physical Review Letters
Publisher
American Physical Society
Citation
Sellon, Jonathan B. et al. "Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections." Physical Review Letters 122, 2 (January 2019): 028101
Version
Final published version
Abstract
Stereociliary imprints in the tectorial membrane (TM) have been taken as evidence that outer hair cells are sensitive to shearing displacements of the TM, which plays a key role in shaping cochlear sensitivity and frequency selectivity via resonance and traveling wave mechanisms. However, the TM is highly hydrated (97% water by weight), suggesting that the TM may be flexible even at the level of single hair cells. Here we show that nanoscale oscillatory displacements of microscale spherical probes in contact with the TM are resisted by frequency-dependent forces that are in phase with TM displacement at low and high frequencies, but are in phase with TM velocity at transition frequencies. The phase lead can be as much as a quarter of a cycle, thereby contributing to frequency selectivity and stability of cochlear amplification.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Research Laboratory of Electronics
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DOI of Published Version
https://doi.org/10.1103/PhysRevLett.122.028101
