Confining a biocatalyst for highly efficient and selective synthesis of carboxamide derivatives under continuous-flow conditions
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Author(s)
Sousa, Bruno A.
Jamison, Timothy F
Helgueira De Andrade, Leandro
Date Issued
April 2016
Journal
Journal of Flow Chemistry
Publisher
Springer International Publishing
Citation
Andrade, Leandro H., et al. “Confining a Biocatalyst for Highly Efficient and Selective Synthesis of Carboxamide Derivatives under Continuous-Flow Conditions.” Journal of Flow Chemistry, vol. 6, no. 2, June 2016, pp. 67–72.
Version
Author's final manuscript
Abstract
The confinement of a biocatalyst designed to operate under continuous-flow conditions is a strategy developed by nature in order to achieve efficient reactions in biological media. Herein, we present a mimetic model that employs a confined lipase (CAL-B) in the production of several carboxamide derivatives from esters as precursors. The remarkable selectivity of such system is also described when α,β-unsatured carboxylic substrates are employed.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1556/1846.2016.00008
