Strategic use of nickel(0)-catalyzed enyne–epoxide reductive coupling toward the synthesis of (−)-cyatha-3,12-diene
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Jamison_Strategic use.pdf
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Author(s)
Sparling, Brian A.
Simpson, Graham L.
Jamison, Timothy F.
Date Issued
November 2008
Journal
Tetrahedron
Publisher
Elsevier
Citation
Sparling, Brian A., Graham L. Simpson, and Timothy F. Jamison. “Strategic Use of Nickel(0)-Catalyzed Enyne–epoxide Reductive Coupling Toward the Synthesis of (−)-Cyatha-3,12-Diene.” Tetrahedron 65, no. 16 (April 2009): 3270–3280.
Version
Author's final manuscript
Abstract
Various situations are explored in which the nickel(0)-catalyzed enyne–epoxide reductive coupling was utilized to access key intermediates toward the total synthesis of (−)-cyatha-3,12-diene (1). Enantioenriched 3,5-dien-1-ols with a variety of functionality were obtained in a straightforward manner from easily accessible 1,3-enynes and terminal epoxides.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-NoDerivatives
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DOI of Published Version
https://doi.org/10.1016/j.tet.2008.11.086
