Methods to Estimate the Comparative Effectiveness of Clinical Strategies that Administer the Same Intervention at Different Times
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40471_2015_Article_45.pdf
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Author(s)
Huitfeldt, Anders
Kalager, Mette
Hoff, Geir
Robins, James M.
Hernan, Miguel Angel
Date Issued
July 2015
Journal
Current Epidemiology Reports
Publisher
Springer International Publishing
Citation
Huitfeldt, Anders, Mette Kalager, James M. Robins, Geir Hoff, and Miguel A. Hernán. “Methods to Estimate the Comparative Effectiveness of Clinical Strategies That Administer the Same Intervention at Different Times.” Curr Epidemiol Rep 2, no. 3 (July 24, 2015): 149–161.
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Author's final manuscript
Abstract
Clinical guidelines that rely on observational data due to the absence of data from randomized trials benefit when the observational data or its analysis emulates trial data or its analysis. In this paper, we review a methodology for emulating trials that compare the effects of different timing strategies, that is, strategies that vary the frequency of delivery of a medical intervention or procedure. We review trial emulation for comparing (i) single applications of the procedure at different times, (ii) fixed schedules of application, and (iii) schedules adapted to the evolving clinical characteristics of the patients. For illustration, we describe an application in which we estimate the effect of surveillance colonoscopies in patients who had an adenoma detected during the Norwegian Colorectal Cancer Prevention (NORCCAP) trial.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1007/s40471-015-0045-5
