Photo-Targeted Nanoparticles
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nihms159012.pdf
Description
Accepted version
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Format
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Author(s)
Dvir, Tal
Banghart, Matthew R.
Timko, Brian P.
Langer, Robert S
Kohane, Daniel S.
Date Issued
November 2009
Journal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Dvir, Tal et al. "Photo-Targeted Nanoparticles." 10, 1 (January 2010): 250-254 © 2010 American Chemical Society
Version
Author's final manuscript
Abstract
We report a novel and simple proof-of-concept of a nanoparticulate system that targets any tissue selectively upon illumination. Nanoparticles were covalently functionalized with the amino acid sequence YIGSR, which adheres to the β1 integrins present on most cell surfaces. This peptide was masked with a caging group, rendering it biologically inert. Illumination with UV light released the caging group from the YIGSR, allowing binding to cells.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biological Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/nl903411s
