Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels
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Anderson_Modular.pdf
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1.01 MB
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Author(s)
Heller, Daniel A.
Levi, Yair
Wallas, Jasmine
Pratt, George W.
Jiang, Shan
Sahay, Gaurav
Schroeder, Josh E.
Chyan, Yieu
Zurenko, Christopher
Querbes, William
Date Issued
December 2012
Journal
Advanced Materials
Publisher
Wiley Blackwell
Citation
Heller, Daniel A., Yair Levi, Jeisa M. Pelet, Joshua C. Doloff, Jasmine Wallas, George W. Pratt, Shan Jiang, et al. “Modular ‘Click-in-Emulsion’ Bone-Targeted Nanogels.” Advanced Materials 25, no. 10 (December 27, 2012): 1449–1454.
Version
Author's final manuscript
Abstract
A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ~70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/adma.201202881
