Ingestible Electronic Sensors for Monitoring Real-time Adherence to HIV Pre-exposure Prophylaxis and Antiretroviral Therapy
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11904_2022_625_ReferencePDF.pdf
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Author(s)
Goodman, Georgia R.
Vaz, Clint
Albrechta, Hannah
Boyer, Edward W.
Mayer, Kenneth H.
O’Cleirigh, Conall
Chai, Peter R.
Date Issued
September 1, 2022
Publisher
Springer US
Citation
Goodman, Georgia R., Vaz, Clint, Albrechta, Hannah, Boyer, Edward W., Mayer, Kenneth H. et al. 2022. "Ingestible Electronic Sensors for Monitoring Real-time Adherence to HIV Pre-exposure Prophylaxis and Antiretroviral Therapy."
Version
Author's final manuscript
Abstract
Abstract
Purpose of Review
This review summarizes the recent advancements and future directions of digital pill systems (DPS) — which utilize ingestible sensors to directly measure medication ingestion events in real-time — in the context of HIV prevention and treatment.
Recent Findings
Two DPS are cleared by the US Food and Drug Administration. The bioequivalence and stability of digitized pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) have been established, and pilot studies have demonstrated the feasibility and acceptability of using DPS for PrEP and ART adherence measurement. Important bioethical and implementation considerations have been identified for future clinical trials. Continued technological advancement may reduce barriers to use, and integration of DPS into behavioral interventions may facilitate adherence improvement efforts.
Summary
DPS represent an innovative tool for PrEP and ART adherence measurement. Future work will optimize the technology to reduce operational barriers. DPS have significant potential for expansion across a diverse array of diseases, though key bioethical considerations must be examined prior to large-scale implementation.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1007/s11904-022-00625-x
