Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties
Name
nanomaterials-07-00063.pdf
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2.11 MB
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Checksum (MD5)
c899159dc49c24a5ff93d865e99d7a62
Author(s)
Memic, Adnan
Aldhahri, Musab
Tamayol, Ali
Mostafalu, Pooria
Abdel-wahab, Mohamed Shaaban
Samandari, Mohamadmahdi
Moghaddam, Kamyar Mollazadeh
Annabi, Nasim
Bencherif, Sidi A.
Khademhosseini, Ali
Date Issued
March 2017
Journal
Nanomaterials
Publisher
MDPI AG
Citation
Memic, Adnan et al. "Nanofibrous Silver-Coated Polymeric Scaffolds with Tunable Electrical Properties." Nanomaterials 7, 3 (2017 March): 63 © 2017 The Author(s)
Version
Final published version
Abstract
Electrospun micro- and nanofibrous poly(glycerol sebacate)-poly(ε-caprolactone) (PGS-PCL) substrates have been extensively used as scaffolds for engineered tissues due to their desirable mechanical properties and their tunable degradability. In this study, we fabricated micro/nanofibrous scaffolds from a PGS-PCL composite using a standard electrospinning approach and then coated them with silver (Ag) using a custom radio frequency (RF) sputtering method. The Ag coating formed an electrically conductive layer around the fibers and decreased the pore size. The thickness of the Ag coating could be controlled, thereby tailoring the conductivity of the substrate. The flexible, stretchable patches formed excellent conformal contact with surrounding tissues and possessed excellent pattern-substrate fidelity. In vitro studies confirmed the platform’s biocompatibility and biodegradability. Finally, the potential controlled release of the Ag coating from the composite fibrous scaffolds could be beneficial for many clinical applications. Keywords: electrospinning; electrical properties; nanocoatings; flexible electronics
MIT Department
Institute for Medical Engineering and Science
Harvard University--MIT Division of Health Sciences and Technology
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3390/nano7030063
