Memory engram storage and retrieval
Name
Tonegawa_Memory engram.pdf
Size
1.14 MB
Format
Adobe PDF
Checksum (MD5)
e9b59c1ac1457bc75f8cf9a75e14bed2
Author(s)
Tonegawa, Susumu
Pignatelli di Spinazzola, Michele
Roy, Dheeraj
Ryan, Tomas John
Date Issued
August 2015
Journal
Current Opinion in Neurobiology
Publisher
Elsevier
Citation
Tonegawa, Susumu, Michele Pignatelli, Dheeraj S Roy, and Tomás J Ryan. “Memory Engram Storage and Retrieval.” Current Opinion in Neurobiology 35 (December 2015): 101–109 © 2015 The Authors
Version
Final published version
Abstract
A great deal of experimental investment is directed towards questions regarding the mechanisms of memory storage. Such studies have traditionally been restricted to investigation of the anatomical structures, physiological processes, and molecular pathways necessary for the capacity of memory storage, and have avoided the question of how individual memories are stored in the brain. Memory engram technology allows the labeling and subsequent manipulation of components of specific memory engrams in particular brain regions, and it has been established that cell ensembles labeled by this method are both sufficient and necessary for memory recall. Recent research has employed this technology to probe fundamental questions of memory consolidation, differentiating between mechanisms of memory retrieval and the true neurobiology of memory storage.
MIT Department
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.conb.2015.07.009
