New Insights into the Troubles of Aneuploidy
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nihms427431.pdf
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Author(s)
Siegel, Jacob
Amon, Angelika B.
Date Issued
July 2012
Journal
Annual Review of Cell and Developmental Biology
Publisher
Annual Reviews
Citation
Siegel, Jake J., and Angelika Amon. “New Insights into the Troubles of Aneuploidy.” Annual Review of Cell and Developmental Biology 28, 1 (November 2012): 189–214 © 2012 Annual Reviews
Version
Author's final manuscript
Abstract
Deviation from a balanced genome by either gain or loss of entire chromosomes is generally tolerated poorly in all eukaryotic systems studied to date. Errors in mitotic or meiotic cell division lead to aneuploidy, which places a burden of additional or insufficient gene products from the missegregated chromosomes on the daughter cells. The burden of aneuploidy often manifests itself as impaired fitness of individual cells and whole organisms, in which abnormal development is also characteristic. However, most human cancers, noted for their rapid growth, also display various levels of aneuploidy. Here we discuss the detrimental, potentially beneficial, and sometimes puzzling effects of aneuploidy on cellular and organismal fitness and tissue function as well as its role in diseases such as cancer and neurodegeneration.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1146/annurev-cellbio-101011-155807
