Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth
Name
Hamrahi-2012-Gram-negative bacter.pdf
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3.1 MB
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Author(s)
Hamrahi, Victoria
Hamblin, Michael R.
Jung, Walter
Benjamin, John B.
Paul, Kasie W.
Fischman, Alan J.
Tompkins, Ronald G.
Carter, Edward A.
Date Issued
April 2012
Journal
Interdisciplinary Perspectives on Infectious Diseases
Publisher
Hindawi Publishing Corporation
Citation
Hamrahi, Victoria et al. “Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth.” Interdisciplinary Perspectives on Infectious Diseases 2012 (2012): 1–6. Web.
Version
Final published version
Abstract
Sepsis remains the major cause of death in patients with major burn injuries. In the present investigation we evaluated the interaction between burn injuries of varying severity and preexisting distant infection. We used Gram-negative bacteria (Pseudomonas aeruginosa and Proteus mirabilis) that were genetically engineered to be bioluminescent, which allowed for noninvasive, sequential optical imaging of the extent and severity of the infection. The bioluminescent bacteria migrated from subcutaneous abscesses in the leg to distant burn wounds on the back depending on the severity of the burn injury, and this migration led to increased mortality of the mice. Treatment with ciprofloxacin, injected either in the leg with the bacterial infection or into the burn eschar, prevented this colonization of the wound and decreased mortality. The present data suggest that burn wounds can readily become colonized by infections distant from the wound itself.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1155/2012/567140
