Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as
Name
Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors.pdf
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1.52 MB
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Checksum (MD5)
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Author(s)
Han, Xiaoxing
Kempa, Thomas J.
Fukumura, Dai
Jain, Rakesh K.
Duda, Dan G.
Nocera, Daniel G.
Lemon, Christopher Michael
Karnas, Elizabeth
Bruns, Oliver Thomas
Bawendi, Moungi G
Date Issued
July 2015
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Lemon, Christopher M.; Karnas, Elizabeth; Han, Xiaoxing; Bruns, Oliver T.; Kempa, Thomas J.; Fukumura, Dai; Bawendi, Moungi G.; Jain, Rakesh K.; Duda, Dan G. and Nocera, Daniel G. “ Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors .” Journal of the American Chemical Society 137, no. 31 (August 2015): 9832–9842 © 2015 American Chemical Society
Version
Author's final manuscript
Abstract
Micelles have been employed to encapsulate the supramolecular assembly of quantum dots with palladium(II) porphyrins for the quantification of O₂ levels in aqueous media and in vivo. Förster resonance energy transfer from the quantum dot (QD) to the palladium porphyrin provides a means for signal transduction under both one- and two-photon excitation. The palladium porphyrins are sensitive to O₂ concentrations in the range of 0–160 Torr. The micelle-encapsulated QD-porphyrin assemblies have been employed for in vivo multiphoton imaging and lifetime-based oxygen measurements in mice with chronic dorsal skinfold chambers or cranial windows. Our results establish the utility of the QD-micelle approach for in vivo biological sensing applications.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/jacs.5b04765
