Palladium(0)-Catalyzed Arylative Dearomatization of Phenols
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Buchwald_Palladium (0).pdf
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Author(s)
Rousseaux, Sophie
Garcia-Fortanet, Jorge
Del Aguila Sanchez, Miguel Angel
Buchwald, Stephen Leffler
Date Issued
May 2011
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Rousseaux, Sophie, Jorge Garcia-Fortanet, Miguel Angel Del Aguila Sanchez, and Stephen L. Buchwald. “Palladium(0)-Catalyzed Arylative Dearomatization of Phenols.” Journal of the American Chemical Society 133, no. 24 (June 22, 2011): 9282-9285.
Version
Author's final manuscript
Abstract
The palladium-catalyzed arylative dearomatization of phenols to yield spirocyclohexadienone products in good to excellent yields has been developed. Preliminary results demonstrate that the formation of the spirocyclic all-carbon quaternary center can be accomplished with high levels of enantiocontrol (up to 91% ee).
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1021/ja203644q
