Catheter based magnetic resonance compatible perfusion probe
Name
214283234-MIT.pdf
Description
Full printable version
Size
5.43 MB
Format
Adobe PDF
Checksum (MD5)
4d5fe13422099b26f1384c051e77dfd7
Author(s)
Toretta, Cara Lynne
Advisor(s)
H. Frederick Bowman.
Date Issued
2007
Publisher
Massachusetts Institute of Technology
Abstract
Neurosurgeons are using a thermal based technique to quantify brain perfusion. The thermal diffusion probe (TDP) technology measures perfusion in a relatively small volume of brain tissue. The neurosurgeon chooses the specific brain location and probe placement based on their clinical concern. When an early indication of compromised perfusion is detected by the TDP, it is generally necessary to confirm the local, absolute perfusion measurement taken with the TDP, with magnetic resonance (MR) perfusion imaging. MR perfusion imaging provides an excellent, but relative, global assessment of compromised tissue perfusion. Due to the many clinical and diagnostic benefits of real-time, absolute quantification of blood flow acquired by the TDP, there has been increased interest in having the TDP MR compatible. This thesis considers what it would take to render the TDP MR compatible in both the active and passive modes. The analysis considers effects of the EM field on the probe, and the probe on the MR image. The presence of cardiac and respiratory induced brain motion has been shown to provide an artifact in TDP-perfusion data. Consideration is given to ways in which to minimize this motion induced perfusion artifact.
Description
Thesis (S.M. and S.B.)--Massachusetts Institute of Technology, Dept. of Nuclear Science and Engineering, 2007.
Includes bibliographical references (leaves 113-117).
Subjects
Nuclear Science and Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Nuclear Science and Engineering
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