Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(ester amide) Elastomers
Name
nihms-603707.pdf
Description
Accepted version
Size
564.59 KB
Format
Adobe PDF
Checksum (MD5)
6e1f8f6a64f42ee034eec2da3426f7c1
Author(s)
Wang, Jane
Boutin, Kyle G
Abdulhadi, Omar
Personnat, Lyndia D
Shazly, Tarek
Langer, Robert
Channick, Colleen L
Borenstein, Jeffrey T
Date Issued
2013
Journal
Advanced Healthcare Materials
Publisher
Wiley
Citation
Wang, J., et al. "Fully Biodegradable Airway Stents Using Amino Alcohol-Based Poly(Ester Amide) Elastomers." Advanced Healthcare Materials 2 10 (2013): 1329-36.
Version
Author's final manuscript
Abstract
Airway stents are often used to maintain patency of the tracheal and bronchial passages in patients suffering from central airway obstruction caused by malignant tumors, scarring, and injury. Like most conventional medical implants, they are designed to perform their functions for a limited period of time, after which surgical removal is often required. Two primary types of airway stents are in general use, metal mesh devices and elastomeric tubes; both are constructed using permanent materials, and must be removed when no longer needed, leading to potential complications. This paper describes the development of process technologies for bioresorbable prototype elastomeric airway stents that would dissolve completely after a predetermined period of time or by an enzymatic triggering mechanism. These airway stents are constructed from biodegradable elastomers with high mechanical strength, flexibility and optical transparency. This work combines microfabrication technology with bioresorbable polymers, with the ultimate goal of a fully biodegradable airway stent ultimately capable of improving patient safety and treatment outcomes. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
MIT Department
Massachusetts Institute of Technology. Department of Mathematics
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/ADHM.201200348
