Roles for MicroRNAs in Conferring Robustness to Biological Processes
Name
Ebert-2012-Roles for MicroRNAs.pdf
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533.58 KB
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Author(s)
Ebert, Margaret S.
Sharp, Phillip A.
Date Issued
April 2012
Journal
Cell
Publisher
Elsevier
Citation
Ebert, Margaret S., and Phillip A. Sharp. “Roles for MicroRNAs in Conferring Robustness to Biological Processes.” Cell 149, no. 3 (April 2012): 515–524. © 2012 Elsevier Inc.
Version
Final published version
Abstract
Biological systems use a variety of mechanisms to maintain their functions in the face of environmental and genetic perturbations. Increasing evidence suggests that, among their roles as posttranscriptional repressors of gene expression, microRNAs (miRNAs) help to confer robustness to biological processes by reinforcing transcriptional programs and attenuating aberrant transcripts, and they may in some network contexts help suppress random fluctuations in transcript copy number. These activities have important consequences for normal development and physiology, disease, and evolution. Here, we will discuss examples and principles of miRNAs that contribute to robustness in animal systems.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.cell.2012.04.005
