Oxidative Addition Complexes as Precatalysts for Cross-Coupling Reactions Requiring Extremely Bulky Biarylphosphine Ligands
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Buchwald_Oxidative addition complexes.pdf
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Author(s)
Ingoglia, Bryan Taylor
Buchwald, Stephen Leffler
Date Issued
June 2017
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Ingoglia, Bryan T. and Stephen L. Buchwald. “Oxidative Addition Complexes as Precatalysts for Cross-Coupling Reactions Requiring Extremely Bulky Biarylphosphine Ligands.” Organic Letters 19, 11 (May 2017): 2853–2856 © 2017 American Chemical Society
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Author's final manuscript
Abstract
In this report, we describe the application of palladium-based oxidative addition complexes (OACs) as effective precatalysts for C-N, C-O, and C-F cross-coupling reactions with a variety of (hetero)arenes. These complexes offer a convenient alternative to previously developed classes of precatalysts, particularly in the case of the bulkiest biarylphosphine ligands, for which palladacycle-based precatalysts do not readily form. The precatalysts described herein are easily prepared and stable to long-term storage under air.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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DOI of Published Version
https://doi.org/10.1021/ACS.ORGLETT.7B01082
