MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte–erythroid progenitor lineage commitment
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Lodish_MicroRNAs in erythroid.pdf
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667.21 KB
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Author(s)
Zhang, L.
Sankaran, Vijay G.
Lodish, Harvey F
Date Issued
May 2012
Journal
Leukemia
Publisher
Nature Publishing Group
Citation
Zhang, L, V G Sankaran, and H F Lodish. “MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte–erythroid progenitor lineage commitment.” Leukemia 26, no. 11 (May 23, 2012): 2310-2316.
Version
Author's final manuscript
Abstract
MicroRNAs (miRNAs) are a class of small regulatory noncoding RNAs that modulate the expression of their target genes through either mRNA degradation or inhibition of protein translation. In recent years, miRNAs have been shown to be critical regulators of hematopoiesis and have important roles in the differentiation of specific lineages. Here, we summarize our current understanding of miRNAs involved in hematopoiesis with a focus on the role of miRNAs in regulating erythroid and megakaryocytic differentiation and megakaryocyte–erythroid progenitor lineage commitment.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/leu.2012.137
