Layer-by-layer functionalized nanotube arrays: A versatile microfluidic platform for biodetection
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Rubner_Layer-by-layer.pdf
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Author(s)
Toner, Mehmet
Yost, Allison Lynne
Shahsavari, Setareh
Bradwell, Grinia M.
Polak, Roberta
Fachin, Fabio
Cohen, Robert E
McKinley, Gareth H
Rubner, Michael F
Wardle, Brian L
Date Issued
October 23, 2017
Journal
Microsystems & Nanoengineering
Publisher
Springer Nature
Citation
Yost, Allison L. et al. “Layer-by-Layer Functionalized Nanotube Arrays: A Versatile Microfluidic Platform for Biodetection.” Microsystems & Nanoengineering 1 (December 2015): 15037
Version
Final published version
Abstract
We demonstrate the layer-by-layer (LbL) assembly of polyelectrolyte multilayers (PEM) on three-dimensional nanofiber scaffolds. High porosity (99%) aligned carbon nanotube (CNT) arrays are photolithographically patterned into elements that act as textured scaffolds for the creation of functionally coated (nano)porous materials. Nanometer-scale bilayers of poly(allylamine hydrochloride)/poly(styrene sulfonate) (PAH/SPS) are formed conformally on the individual nanotubes by repeated deposition from aqueous solution in microfluidic channels. Computational and experimental results show that the LbL deposition is dominated by the diffusive transport of the polymeric constituents, and we use this understanding to demonstrate spatial tailoring on the patterned nanoporous elements. A proof-of-principle application, microfluidic bioparticle capture using N-hydroxysuccinimide-biotin binding for the isolation of prostate-specific antigen (PSA), is demonstrated.
MIT Department
Massachusetts Institute of Technology. Department of Aeronautics and Astronautics
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1038/micronano.2015.37
