Gene Copy-Number Alterations: A Cost-Benefit Analysis
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Amon_Gene copy.pdf
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2.17 MB
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Adobe PDF
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Author(s)
Tang, Yun-Chi
Amon, Angelika B
Date Issued
January 2013
Journal
Cell
Publisher
Elsevier
Citation
Tang, Yun-Chi, and Angelika Amon. “Gene Copy-Number Alterations: A Cost-Benefit Analysis.” Cell 152, no. 3 (January 2013): 394–405.
Version
Author's final manuscript
Abstract
Changes in DNA copy number, whether confined to specific genes or affecting whole chromosomes, have been identified as causes of diseases and developmental abnormalities and as sources of adaptive potential. Here, we discuss the costs and benefits of DNA copy-number alterations. Changes in DNA copy number are largely detrimental. Amplifications or deletions of specific genes can elicit discrete defects. Large-scale changes in DNA copy number can also cause detrimental phenotypes that are due to the cumulative effects of copy-number alterations of many genes simultaneously. On the other hand, studies in microorganisms show that DNA copy-number alterations can be beneficial, increasing survival under selective pressure. As DNA copy-number alterations underlie many human diseases, we will end with a discussion of gene copy-number changes as therapeutic targets.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-NoDerivatives
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DOI of Published Version
https://doi.org/10.1016/j.cell.2012.11.043
