Mobile zinc as a modulator of sensory perception
Name
FEBS Letters - 2022 - Goldberg - Mobile zinc as a modulator of sensory perception.pdf
Description
Published version
Size
2.26 MB
Format
Adobe PDF
Checksum (MD5)
2843029631e966dafb5630b96d3948d7
Author(s)
Goldberg, Jacob M
Lippard, Stephen J
Date Issued
January 2023
Journal
FEBS Letters
Publisher
Wiley
Citation
Goldberg, Jacob M and Lippard, Stephen J. 2023. "Mobile zinc as a modulator of sensory perception." FEBS Letters, 597 (1).
Version
Final published version
Abstract
Mobile zinc is an abundant transition metal ion in the central nervous system, with pools of divalent zinc accumulating in regions of the brain engaged in sensory perception and memory formation. Here, we present essential tools that we developed to interrogate the role(s) of mobile zinc in these processes. Most important are (a) fluorescent sensors that report the presence of mobile zinc and (b) fast, Zn-selective chelating agents for measuring zinc flux in animal tissue and live animals. The results of our studies, conducted in collaboration with neuroscientist experts, are presented for sensory organs involved in hearing, smell, vision, and learning and memory. A general principle emerging from these studies is that the function of mobile zinc in all cases appears to be downregulation of the amplitude of the response following overstimulation of the respective sensory organs. Possible consequences affecting human behavior are presented for future investigations in collaboration with interested behavioral scientists.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/1873-3468.14544
