A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2

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sword-2022-03-09T15:48:02.original.xml (130 B)
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Author(s)
Gopalsamuthiram, Vijayagopal
•
Williams, Corshai
•
Noble, Jeffrey
•
Jamison, Tim
•
Gupton, B Frank
•
Snead, David R
Date Issued
2021
Journal
Synlett
Publisher
Georg Thieme Verlag KG
Citation
Gopalsamuthiram, Vijayagopal, Williams, Corshai, Noble, Jeffrey, Jamison, Tim, Gupton, B Frank et al. 2021. "A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2." Synlett, 32 (03).
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Original manuscript
Abstract
© 2021 Georg Thieme Verlag. All rights reserved. A new route to MK-4482 was developed. The route replaces uridine with the more available and less expensive cytidine. Low-cost, simple reagents are used for the chemical transformations, and the yield is improved from 17% to 44%. A step is removed from the longest linear sequence, and these advancements are expected to expand access to MK-4482 should it become a viable drug substance.
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
10.1055/A-1275-2848
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