We are experiencing minor difficulties with our submission forms, which we are working to resolve. If you have any issues while submitting items, please contact us at dspace-lib@mit.edu.

A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2

Thumbnail Image
Download
Name

a-concise-route-to-mk-4482-eidd-2801-from-cytidine-part-2.pdf

Description
Submitted version
Size

73.16 KB

Format

Adobe PDF

Checksum (MD5)

04d16f33187c26f54315f06e26dd0668

sword-2022-03-09T15:48:02.original.xml (130 B)
Original SWORD entry document
Author(s)
Gopalsamuthiram, Vijayagopal
•
Williams, Corshai
•
Noble, Jeffrey
•
Jamison, Tim
•
Gupton, B Frank
•
Snead, David R
Date Issued
2021
Journal
Synlett
Publisher
Georg Thieme Verlag KG
Citation
Gopalsamuthiram, Vijayagopal, Williams, Corshai, Noble, Jeffrey, Jamison, Tim, Gupton, B Frank et al. 2021. "A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2." Synlett, 32 (03).
Version
Original manuscript
Abstract
© 2021 Georg Thieme Verlag. All rights reserved. A new route to MK-4482 was developed. The route replaces uridine with the more available and less expensive cytidine. Low-cost, simple reagents are used for the chemical transformations, and the yield is improved from 17% to 44%. A step is removed from the longest linear sequence, and these advancements are expected to expand access to MK-4482 should it become a viable drug substance.
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
10.1055/A-1275-2848
PrivacyPermissionsAccessibilityContact us
Notify us about copyright concerns.