Interaction of N-nitrosamines with binuclear copper complexes for luminescent detection
Name
d2dt03848j.pdf
Description
Published version
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2.69 MB
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Adobe PDF
Checksum (MD5)
60d54a018d850881e74b6be134cebad8
Author(s)
Feng, Haosheng
Luo, Shao-Xiong Lennon
Croy, Robert G
Essigmann, John M
Swager, Timothy M
Date Issued
February 17, 2023
Journal
Dalton Transactions
Publisher
Royal Society of Chemistry (RSC)
Citation
Feng, Haosheng, Luo, Shao-Xiong Lennon, Croy, Robert G, Essigmann, John M and Swager, Timothy M. 2023. "Interaction of N-nitrosamines with binuclear copper complexes for luminescent detection." Dalton Transactions.
Version
Final published version
Abstract
Cu(I) from tetrakis(acetonitrile)copper(I) hexafluorophosphate ([Cu(MeCN)4]PF6) was complexed with five structurally related phosphines containing N-heterocycles. The interactions between the resulting complexes and some N-nitrosamines were studied using X-ray crystallography as well as emission spectroscopy. Upon complexation, three phosphine ligands bridge two Cu(I) centers to give paddlewheel type structures that displayed a range of emission wavelengths spanning the visible region. N-Nitrosodimethylamine (NDMA) was shown to coordinate to one of the two copper centers in some of the paddlewheel complexes in the solid state and this interaction also quenches their emissions in solution. The influence of the weakly coordinating anion on crystal and spectroscopic properties of one of the paddlewheel complexes was also examined using tetrakis(acetonitrile)copper(I) perchlorate ([Cu(MeCN)4]ClO4) as an alternative Cu(I) source. Similarly, copper(II) perchlorate hexahydrate (Cu(ClO4)2·6H2O) was used for complexation to observe the impact of metal oxidation state on the two aforementioned properties. Lastly, the spectroscopic properties of the complex between Ph2P(1-Isoquinoline) and Cu(I) was shown to exhibit solvent dependence when the counterion is ClO4−. These Cu(I) complexes are bench stable solids and may be useful materials for developing a fluorescence based detection method for N-nitrosamines.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Biological Engineering
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Creative Commons Attribution NonCommercial License 3.0
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DOI of Published Version
https://doi.org/10.1039/d2dt03848j
