Porous microwells for geometry-selective, large-scale microparticle arrays
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Porous microwells.pdf
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2.11 MB
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Author(s)
Bong, Ki Wan
Reátegui, Eduardo
Irimia, Daniel
Kim, Jae Jung
Doyle, Patrick S
Date Issued
September 2016
Journal
Nature Materials
Publisher
Nature Publishing Group
Citation
Kim, Jae Jung et al. “Porous Microwells for Geometry-Selective, Large-Scale Microparticle Arrays.” Nature Materials 16.1 (2016): 139–146.
Version
Author's final manuscript
Abstract
Large-scale microparticle arrays (LSMAs) are key for material science and bioengineering applications. However, previous approaches suffer from trade-offs between scalability, precision, specificity and versatility. Here, we present a porous microwell-based approach to create large-scale microparticle arrays with complex motifs. Microparticles are guided to and pushed into microwells by fluid flow through small open pores at the bottom of the porous well arrays. A scaling theory allows for the rational design of LSMAs to sort and array particles on the basis of their size, shape, or modulus. Sequential particle assembly allows for proximal and nested particle arrangements, as well as particle recollection and pattern transfer. We demonstrate the capabilities of the approach by means of three applications: high-throughput single-cell arrays; microenvironment fabrication for neutrophil chemotaxis; and complex, covert tags by the transfer of an upconversion nanocrystal-laden LSMA.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1038/NMAT4747
