A miniature CSTR cascade for continuous flow of reactions containing solids
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Jensen_A miniature.pdf
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Author(s)
Mo, Yiming
Jensen, Klavs F
Date Issued
August 2016
Journal
Reaction Chemistry & Engineering
Publisher
Royal Society of Chemistry, The
Citation
Mo, Yiming and Jensen, Klavs F. “A Miniature CSTR Cascade for Continuous Flow of Reactions Containing Solids.” Reaction Chemistry & Engineering 1, no. 5 (August 2016): 501–507. © 2016 The Royal Society of Chemistry
Version
Final published version
Abstract
Continuous handling of solids creates challenges for realizing continuous production of pharmaceuticals and fine chemicals. We present a new miniature continuous stirred-tank reactor (CSTR) cascade to handle solid-forming reactions in flow. Single-phase residence time distribution (RTD) measurements of the CSTR cascade reveal nearly ideal CSTR mixing behavior of the individual units. Consistency of experimental and predicted conversions of a Diels–Alder reaction further confirms the CSTR performance. Two solid-forming reactions, (i) glyoxal reacting with cyclohexylamine to form N,N′-dicyclohexylethylenediimine, (ii) sulfonylation of 2-octanol with methanesulfonyl chloride, demonstrate the ability of the reactor cascade to transport solid particles continuously for hours without significant signs of clogging.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution 3.0 Unported license
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DOI of Published Version
https://doi.org/10.1039/C6RE00132G
