Disruption of Ripple-Associated Hippocampal Activity During Rest Impairs Spatial Learning in the Rat
Name
Wilson-2010-Disruption of Ripple.pdf
Size
577.75 KB
Format
Adobe PDF
Checksum (MD5)
de3bea79939cf3c4e566a9a44c741a57
Author(s)
Ego-Stengel, Valérie
Wilson, Matthew A.
Date Issued
October 2009
Journal
Hippocampus
Publisher
Wiley Blackwell (John Wiley & Sons)
Citation
Ego-Stengel, Valérie, and Matthew A. Wilson. “Disruption of Ripple-associated Hippocampal Activity During Rest Impairs Spatial Learning in the Rat.” Hippocampus (2009): Web. 27 Apr. 2012. © 2009 Wiley-Liss, Inc.
Version
Author's final manuscript
Abstract
The hippocampus plays a key role in the acquisition of new memories for places and events. Evidence suggests that the consolidation of these memories is enhanced during sleep. At the neuronal level, reactivation of awake experience in the hippocampus during sharp-wave ripple events, characteristic of slow-wave sleep, has been proposed as a neural mechanism for sleep-dependent memory consolidation. However, a causal relation between sleep reactivation and memory consolidation has not been established. Here we show that disrupting neuronal activity during ripple events impairs spatial learning. We trained rats daily in two identical spatial navigation tasks followed each by a 1-hour rest period. After one of the tasks, stimulation of hippocampal afferents selectively disrupted neuronal activity associated with ripple events without changing the sleep-wake structure. Rats learned the control task significantly faster than the task followed by rest stimulation, indicating that interfering with hippocampal processing during sleep led to decreased learning.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
RIKEN-MIT Center for Neural Circuit Genetics
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/hipo.20707
