Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation
Name
1-s2.0-S2213671120300369-main.pdf
Description
Published version
Size
3.57 MB
Format
Unknown
Checksum (MD5)
ab10b7bba136cf66efd066f9270d58f7
Author(s)
Smith-Geater, Charlene
Hernandez, Sarah J
Lim, Ryan G
Adam, Miriam
Wu, Jie
Stocksdale, Jennifer T
Wassie, Brook T
Gold, Maxwell Philip
Wang, Keona Q
Miramontes, Ricardo
Date Issued
2020
Journal
Stem Cell Reports
Publisher
Elsevier BV
Version
Final published version
Abstract
© 2020 The Authors Thompson et al. describe a cyclin D1+ neural stem cell population unique to adult-onset Huntington's disease iPSC-derived neuronal cultures, differentiated using a protocol that increases the derivation of medium spiny neurons. These findings highlight a selective CAG-length-dependent deficit in neurodevelopment. This aberrant mitotic population is ameliorated with WNT inhibition, perhaps identifying a mechanism that can be exploited for therapeutic compensation.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.stemcr.2020.01.015
