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Diagnosing and Preventing Hearing Loss in the Genomic Age
Name
2331216519878983.pdf
Description
Published version
Size
423.5 KB
Format
Adobe PDF
Checksum (MD5)
40bff15aef34d172355bcc1c6b5be7ef
Author(s)
McDermott, JH
Molina-Ramírez, LP
Bruce, IA
Mahaveer, A
Turner, M
Miele, G
Body, R
Mahood, R
Ulph, F
MacLeod, R
Date Issued
January 1, 2019
Journal
Trends in Hearing
Publisher
SAGE Publications
Version
Final published version
Abstract
© The Author(s) 2019. Over the past two decades, significant technological advances have facilitated the identification of hundreds of genes associated with hearing loss. Variants in many of these genes result in severe congenital hearing loss with profound implications for the affected individual and their family. This review collates these advances, summarizing the current state of genomic knowledge in childhood hearing loss. We consider how current and emerging genetic technologies have the potential to alter our approach to the management and diagnosis of hearing loss. We review approaches being taken to ensure that these discoveries are used in clinical practice to detect genetic hearing loss as soon as possible to reduce unnecessary investigations, provide information about reproductive risks, and facilitate regular follow-up and early treatment. We also highlight how rapid sequencing technology has the potential to identify children susceptible to antibiotic-induced hearing loss and how this adverse reaction can be avoided.
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
Persistent DSpace Link
DOI of Published Version
10.1177/2331216519878983
