Gamete Formation Resets the Aging Clock in Yeast
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nihms-414009.pdf
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1.85 MB
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Author(s)
Unal, Elcin
Amon, Angelika B
Date Issued
September 2011
Journal
Cold Spring Harbor Symposia on Quantitative Biology
Publisher
Cold Spring Harbor Laboratory
Citation
Unal, E., and A. Amon. “Gamete Formation Resets the Aging Clock in Yeast.” Cold Spring Harbor Symposia on Quantitative Biology 76, no. 0 (January 1, 2011): 73–80.
Version
Author's final manuscript
Abstract
Gametogenesis is a process whereby a germ cell differentiates into haploid gametes. We found that, in budding yeast, replicatively aged cells remove age-induced cellular damage during gametogenesis. Importantly, gametes of aged cells have the same replicative potential as those derived from young cells, indicating that life span resets during gametogenesis. Here, we explore the potential mechanisms responsible for gametogenesis-induced rejuvenation and discuss putative analogous mechanisms in higher eukaryotes.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1101/sqb.2011.76.011379
