Effects of Age on Meiosis in Budding Yeast
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Amon_Effect of.pdf
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Author(s)
Boselli, Monica
Rock, Jeremy Michael
Unal, Elcin
Levine, Stuart S.
Amon, Angelika B
Date Issued
June 2009
Journal
Developmental Cell
Publisher
Elsevier
Citation
Boselli, Monica et al. “Effects of Age on Meiosis in Budding Yeast.” Developmental Cell 16.6 (2009): 844–855.
Version
Author's final manuscript
Abstract
In humans, the frequency with which meiotic chromosome mis-segregation occurs increases with age. Whether age-dependent meiotic defects occur in other organisms is unknown. Here, we examine the effects of replicative aging on meiosis in budding yeast. We find that aged mother cells show a decreased ability to initiate the meiotic program and fail to express the meiotic inducer IME1. The few aged mother cells that do enter meiosis complete this developmental program but exhibit defects in meiotic chromosome segregation and spore formation. Furthermore, we find that mutations that extend replicative life span also extend the sexual reproductive life span. Our results indicate that in budding yeast, the ability to initiate and complete the meiotic program as well as the fidelity of meiotic chromosome segregation decrease with cellular age and are controlled by the same pathways that govern aging of asexually reproducing yeast cells.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.devcel.2009.05.013
