Thermally drawn fibers as nerve guidance scaffolds
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Anikeeva_Thermally drawn.pdf
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1.55 MB
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Author(s)
Achyuta, Anilkumar Harapanahalli
Koppes, Ryan
Park, Seongjun
Hood, Tiffany Tamara
Jia, Xiaoting
Abdolrahim Poorheravi, Negin
Fink, Yoel
Anikeeva, Polina Olegovna
Date Issued
December 2015
Journal
Biomaterials
Publisher
Elsevier
Citation
Koppes, Ryan A. et al. “Thermally Drawn Fibers as Nerve Guidance Scaffolds.” Biomaterials 81 (March 2016): 27–35 © 2015 Elsevier
Version
Author's final manuscript
Abstract
Synthetic neural scaffolds hold promise to eventually replace nerve autografts for tissue repair following peripheral nerve injury. Despite substantial evidence for the influence of scaffold geometry and dimensions on the rate of axonal growth, systematic evaluation of these parameters remains a challenge due to limitations in materials processing. We have employed fiber drawing to engineer a wide spectrum of polymer-based neural scaffolds with varied geometries and core sizes. Using isolated whole dorsal root ganglia as an in vitro model system we have identified key features enhancing nerve growth within these fiber scaffolds. Our approach enabled straightforward integration of microscopic topography at the scale of nerve fascicles within the scaffold cores, which led to accelerated Schwann cell migration, as well as neurite growth and alignment. Our findings indicate that fiber drawing provides a scalable and versatile strategy for producing nerve guidance channels capable of controlling direction and accelerating the rate of axonal growth. Keywords:
Peripheral nerve repair; Neural scaffold; Fiber drawing; Tissue engineering
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Research Laboratory of Electronics
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.biomaterials.2015.11.063
