Sickle Cell MicroRNAs Inhibit the Malaria Parasite
Name
Duraisingh-2012-Sickle Cell MicroRNA.pdf
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185.52 KB
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Author(s)
Duraisingh, Manoj T.
Lodish, Harvey F
Date Issued
August 2012
Journal
Cell Host & Microbe
Publisher
Elsevier B.V.
Citation
Duraisingh, Manoj T., and Harvey F. Lodish. “Sickle Cell MicroRNAs Inhibit the Malaria Parasite.” Cell Host & Microbe 12, no. 2 (August 2012): 127–128. © 2012 Elsevier Inc.
Version
Final published version
Abstract
Sickle cell hemoglobin conveys resistance to malaria. In this issue of Cell Host & Microbe, LaMonte et al. (2012) demonstrate a surprising mechanism for this innate immunity. A microRNA enriched in sickle red blood cells is translocated into the parasite, incorporated covalently into P. falciparum mRNAs and inhibits parasite growth.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.chom.2012.08.001
