Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer
Name
nihms-789640.pdf
Size
2.86 MB
Format
Adobe PDF
Checksum (MD5)
bf9e0523bf2f825cc8b68833b76e9143
Date Issued
June 2016
Journal
Cell
Publisher
Elsevier BV
Citation
Zhang, Hui et al. “Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer.” Cell 166, 3 (July 2016): 755–765
Version
Author's final manuscript
Abstract
To provide a detailed analysis of the molecular components and underlying mechanisms associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based proteomic characterization of 174 ovarian tumors previously analyzed by The Cancer Genome Atlas (TCGA), of which 169 were high-grade serous carcinomas (HGSCs). Integrating our proteomic measurements with the genomic data yielded a number of insights into disease, such as how different copy-number alternations influence the proteome, the proteins associated with chromosomal instability, the sets of signaling pathways that diverse genome rearrangements converge on, and the ones most associated with short overall survival. Specific protein acetylations associated with homologous recombination deficiency suggest a potential means for stratifying patients for therapy. In addition to providing a valuable resource, these findings provide a view of how the somatic genome drives the cancer proteome and associations between protein and post-translational modification levels and clinical outcomes in HGSC.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/J.CELL.2016.05.069
