Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers
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Alexander-Katz_Effect of particle.pdf
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Author(s)
Van Lehn, Reid C.
Atukorale, Prabhani U.
Carney, Randy P.
Yang, Yu-Sang Sabrina
Stellacci, Francesco
Irvine, Darrell J.
Alexander-Katz, Alfredo
Date Issued
August 2013
Journal
Nano Letters
Publisher
American Chemical Society (ACS)
Citation
Van Lehn, Reid C., Prabhani U. Atukorale, Randy P. Carney, Yu-Sang Yang, Francesco Stellacci, Darrell J. Irvine, and Alfredo Alexander-Katz. “Effect of Particle Diameter and Surface Composition on the Spontaneous Fusion of Monolayer-Protected Gold Nanoparticles with Lipid Bilayers.” Nano Lett. 13, no. 9 (September 11, 2013): 4060–4067.
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Author's final manuscript
Abstract
Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the penetration process is potentially the fusion of such AuNPs with lipid bilayers. Free energy calculations, experiments on unilamellar and multilamellar vesicles, and cell studies all support this hypothesis. Furthermore, we show that fusion is only favorable for AuNPs with core diameters below a critical size that depends on the monolayer composition.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Koch Institute for Integrative Cancer Research at MIT
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DOI of Published Version
https://doi.org/10.1021/nl401365n
