Optical Pooled Screens in Human Cells
Name
nihms-1056812.pdf
Description
Accepted version
Size
2.65 MB
Format
Adobe PDF
Checksum (MD5)
49437e73c7d9cf835e29beca60c32606
Author(s)
Feldman, David
Singh, Avtar
Schmid-Burgk, Jonathan
Carlson, Rebecca J.
Mezger, Anja
Garrity, Anthony J.
Zhang, Feng
Blainey, Paul C
Date Issued
October 2019
Journal
Cell
Publisher
Elsevier BV
Citation
Feldman, David et al. "Optical Pooled Screens in Human Cells." Cell 179, 3 (October 2019): P787-799.e17 © 2019 Elsevier
Version
Author's final manuscript
Abstract
A screening approach that combines high-content imaging with in situ sequencing can identify genes that affect spatially and temporally defined phenotypes like morphology and subcellular localization, expanding the list of scientific questions that can be asked with genetic tools.
MIT Department
Massachusetts Institute of Technology. Department of Physics
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biological Engineering
McGovern Institute for Brain Research at MIT
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Broad Institute of MIT and Harvard
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.cell.2019.09.016
