Understanding the Intersections between Metabolism and Cancer Biology
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nihms848132.pdf
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1.35 MB
Format
Adobe PDF
Checksum (MD5)
13a4e4fb334c7d94beba980ede771d1b
Author(s)
Vander Heiden, Matthew G.
DeBerardinis, Ralph J.
Date Issued
February 2017
Journal
Cell
Publisher
Elsevier BV
Citation
Vander Heiden, Matthew G., and Ralph J. DeBerardinis. “Understanding the Intersections Between Metabolism and Cancer Biology.” Cell 168, no. 4 (February 2017): 657–669.
Version
Author's final manuscript
Abstract
Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CELL.2016.12.039
