mTOR: from growth signal integration to cancer, diabetes and ageing
Name
Sabatini_mTOR from.pdf
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2.74 MB
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Adobe PDF
Checksum (MD5)
552492ccb3b72c48e82f5e46b1aff8d9
Author(s)
Zoncu, Roberto
Efeyan, Alejo
Sabatini, David
Date Issued
December 2010
Journal
Nature Reviews Molecular Cell Biology
Publisher
Nature Publishing Group
Citation
Zoncu, Roberto, Alejo Efeyan, and David M. Sabatini. “mTOR: From Growth Signal Integration to Cancer, Diabetes and Ageing.” Nature Reviews Molecular Cell Biology 12.1 (2010): 21–35.
Version
Author's final manuscript
Abstract
In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy
and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense energy, nutrients and stress and, in metazoans, growth factors. Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt. In the past few years, a significant advance in our understanding of the regulation and functions of mTOR has revealed the crucial involvement of this signalling pathway in the onset and progression of diabetes, cancer and ageing.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/nrm3025
