Cellular Decision Making and Biological Noise: From Microbes to Mammals
Name
Balázsi-2011-Cellular Decision Ma.pdf
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1.02 MB
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Adobe PDF
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Author(s)
Balazsi, Gabor
van Oudenaarden, Alexander
Collins, James J.
van Oudenaarden, Alexander
Date Issued
March 2011
Journal
Cell
Publisher
Elsevier
Citation
Balazsi, Gabor, Alexander van Oudenaarden, and James J. Collins. “Cellular Decision Making and Biological Noise: From Microbes to Mammals.” Cell 144, no. 6 (March 2011): 910–925. © 2011 Elsevier Inc.
Version
Final published version
Abstract
Cellular decision making is the process whereby cells assume different, functionally important and heritable fates without an associated genetic or environmental difference. Such stochastic cell fate decisions generate nongenetic cellular diversity, which may be critical for metazoan development as well as optimized microbial resource utilization and survival in a fluctuating, frequently stressful environment. Here, we review several examples of cellular decision making from viruses, bacteria, yeast, lower metazoans, and mammals, highlighting the role of regulatory network structure and molecular noise. We propose that cellular decision making is one of at least three key processes underlying development at various scales of biological organization.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Physics
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1016/j.cell.2011.01.030
