Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand
Name
Lippard_Photoluminescent DNA.pdf
Size
1009.86 KB
Format
Adobe PDF
Checksum (MD5)
8d887ec0f1740582d12037a8a4ca4a6b
Author(s)
Hope, Jennifer M.
Wilson, Justin J.
Lippard, Stephen J.
Date Issued
November 2012
Journal
Dalton Transactions
Publisher
Royal Society of Chemistry, The
Citation
Hope, Jennifer M., Justin J. Wilson, and Stephen J. Lippard. “Photoluminescent DNA Binding and Cytotoxic Activity of a Platinum(ii) Complex Bearing a Tetradentate β-Diketiminate Ligand.” Dalton Transactions 42, no. 9 (2013): 3176.
Version
Author's final manuscript
Abstract
A platinum(II) complex of a monoanionic, tetradentate β-diketiminate (BDI) ligand with pendant quinoline arms, BDIQQH, is reported. The complex, [Pt(BDI[superscript QQ])]Cl, is emissive in DMSO, but non-emissive in aqueous buffer. Upon binding DNA in buffer, however, a 150-fold turn-on in emission intensity occurs. Dynamic light scattering and [superscript 1]H NMR spectroscopy indicate that [Pt(BDI[superscript QQ])]Cl forms non-emissive aggregates in aqueous solution; DNA-binding disperses the aggregates leading to the large emission turn-on response. The cytotoxic activity of the complex, measured in two cancer cell lines, is comparable to or better than that of the established anticancer drug cisplatin.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1039/c2dt32462h
