Functional specialization of ribosomes?
Name
Gilbert_Functional Specialization.pdf
Size
59.44 KB
Format
Adobe PDF
Checksum (MD5)
62f95740f8fc17504b4d1f9d7c6d6b7e
Author(s)
Gilbert, Wendy
Date Issued
January 2011
Journal
Trends in Biochemical Sciences
Publisher
Elsevier
Citation
Gilbert, Wendy V. “Functional Specialization of Ribosomes?” Trends in Biochemical Sciences 36, no. 3 (March 2011): 127–132.
Version
Author's final manuscript
Abstract
Ribosomes are highly conserved macromolecular machines that are responsible for protein synthesis in all living organisms. Work published in the past year has shown that changes to the ribosome core can affect the mechanism of translation initiation that is favored in the cell, which potentially leads to specific changes in the relative efficiencies with which different proteins are made. Here, I examine recent data from expression and proteomic studies that suggest that cells make slightly different ribosomes under different growth conditions, and discuss genetic evidence that such differences are functional. In particular, I argue that eukaryotic cells probably produce ribosomes that lack one or more core ribosomal proteins (RPs) under some conditions, and that core RPs contribute differentially to translation of distinct subpopulations of mRNAs.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-Noncommercial-NoDerivatives
Persistent DSpace Link
DOI of Published Version
http://dx.doi.org/10.1016/j.tibs.2010.12.002
