PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity
Name
Xu_PSD-95-like membrane associated.pdf
Size
360.96 KB
Format
Adobe PDF
Checksum (MD5)
1df0e18e26b8ad510f7bd00630e72603
Author(s)
Xu, Weifeng
Date Issued
March 2011
Journal
Current Opinion in Neurobiology
Publisher
Elsevier
Citation
Xu, Weifeng. “PSD-95-like Membrane Associated Guanylate Kinases (PSD-MAGUKs) and Synaptic Plasticity.” Current Opinion in Neurobiology 21, no. 2 (April 2011): 306–12.
Version
Author's final manuscript
Abstract
Activity-dependent modification of excitatory synaptic transmission is a fundamental mechanism for developmental plasticity of the neural circuits and experience-dependent plasticity. Synaptic glutamatergic receptors including AMPA receptors and NMDA receptors (AMPARs and NMDARs) are embedded in the postsynaptic density, a highly organized protein network. Overwhelming data have shown that PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs), a major family of scaffold proteins at glutamatergic synapses, regulate basal synaptic AMPAR function and trafficking. It is now clear that PSD-MAGUKs have multifaceted functions in regulating both basal synaptic transmission and synaptic plasticity. Here we discuss recent advancements in understanding the roles of PSD-95 and other family members of PSD-MAGUKs in synaptic plasticity, both as an anchoring protein for synaptic AMPARs and as a signaling scaffold for mediating the interaction of the signaling complex and NMDARs.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Creative Commons Attribution-Noncommercial-NoDerivatives
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.conb.2011.03.001
