Glycans as receptors for influenza pathogenesis
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Viswanathan_2010-Glycans as receptors.pdf
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Author(s)
Viswanathan, Karthik
Chandrasekaran, Aarthi
Srinivasan, Aravind
Raman, Rahul
Sasisekharan, V.
Sasisekharan, Ram
Date Issued
August 2010
Journal
Glycoconjugate Journal
Citation
Viswanathan, Karthik, Aarthi Chandrasekaran, Aravind Srinivasan, Rahul Raman, V. Sasisekharan, and Ram Sasisekharan. “Glycans as receptors for influenza pathogenesis.” Glycoconjugate Journal 27, no. 6 (August 24, 2010): 561-570.
Version
Final published version
Abstract
Influenza A viruses, members of the Orthomyxoviridae family, are responsible for annual seasonal influenza epidemics and occasional global pandemics. The binding of viral coat glycoprotein hemagglutinin (HA) to sialylated glycan receptors on host epithelial cells is the critical initial step in the infection and transmission of these viruses. Scientists believe that a switch in the binding specificity of HA from Neu5Acα2-3Gal linked (α2-3) to Neu5Acα2-6Gal linked (α2-6) glycans is essential for the crossover of the viruses from avian to human hosts. However, studies have shown that the classification of glycan binding preference of HA based on sialic acid linkage alone is insufficient to establish a correlation between receptor specificity of HA and the efficient transmission of influenza A viruses. A recent study reported extensive diversity in the structure and composition of α2-6 glycans (which goes beyond the sialic acid linkage) in human upper respiratory epithelia and identified different glycan structural topologies. Biochemical examination of the multivalent HA binding to these diverse sialylated glycan structures also demonstrated that high affinity binding of HA to α2-6 glycans with a characteristic umbrella-like structural topology is critical for efficient human adaptation and human-human transmission of influenza A viruses. This review summarizes studies which suggest a new paradigm for understanding the role of the structure of sialylated glycan receptors in influenza virus pathogenesis.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. School of Engineering
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DOI of Published Version
https://doi.org/10.1007/s10719-010-9303-4
